To evaluate any independent effects of anti-IL-6 antibody on CC3 and behavioral function, we administered anti-IL-6 antibody or saline to non-UTI wild-type mice (n = 6/group) and found no difference in frontal/hippocampal CC3 expression or behavioral function (Additional file 1: Fig. S3A–M). Here, IL6 is linked to bacterial urinary tract infection.