A previous study in a mouse model of sepsis from this laboratory showed that CXCR5 contributes to hippocampal neuroinflammation, subsequently leading to hippocampal neurogenesis disorder and cognitive impairment, and CXCR5 deficiency alleviates sepsis-induced deficits in hippocampal neurogenesis and cognitive function [22]. Here, CXCR5 is linked to Cognitive impairment.