There was no difference in age, BMI, DBP, WC, HC, TG, TC, LDL-c and FINS among groups (P > 0.05); while SBP, WHR, FBG, 2hPG, 2 h INS, IAF area, HOMA-IR, and 8-iso-PGF2α were all increased, and HDL-C decreased in Prediabetic group, New-onset T2DM, and non-new onset T2DM groups compared to the NC group (P < 0.05). The gene discussed is INS; the disease is type 2 diabetes mellitus.