For example, one or more individuals who developed a therapy-resistant epileptic encephalopathy have been observed in families with BFNS1 [13–15]; the p.Arg213Trp KCNQ2 pathogenic variant has been reported in an individual with severe epileptic encephalopathy [16] and in another family with normal outcome [17]. The gene discussed is KCNQ2; the disease is Epileptic encephalopathy.