In keeping with the known binding of FOXM1 to DNA sequences termed cell cycle gene homology regions (CHR) via its interaction with the MuvB complex [9] several of the most highly correlated genes were regulators or markers of cell cycle progression (CCNB2, MKI67, TPX2 & BIRC5), suggesting that FOXM1 may serve to sustain post-chemotherapy AML cell proliferation (Figs. 3E-F and S3A). This evidence concerns the gene TPX2 and acute myeloid leukemia.