ROCK1 and Diarrhea: 2001; Patel and Rattan 2007; Kim et al. 2008; Wu et al. 2018). Our study showed that the increased ROCK-1 and MLCK expression was easily observed in the antrum and intestine of diarrhoea rats, both of which were significantly inhibited by WCA (Figure 7(B)). In contrast, ROCK-1 and MLCK expressions were decreased in Constipated rats, and further elevated by WCA administration (Figure 8(B)).