Moreover, (Fan et al., 2016) determined in their meta-analysis that PNPLA3 (I148M) GG was associated with the risk of both advanced liver fibrosis and steatosis among Caucasians but not Asian populations, and they confirmed the relatedness of this polymorphism and liver disease susceptibility in HCV infection patients. The gene discussed is PNPLA3; the disease is Hepatic fibrosis.