ASPG and acute lymphoblastic leukemia: A study in adult ALL age 17 to 71 revealed that patients who could not maintain plasma asparaginase activity greater than 0.03 IU/ml at post-14 days had inferior overall survival (OS) (p = 0.002; HR = 2.37; 95% CI = 1.38-4.09) and reduced disease-free survival (DFS) (p = 0.012; HR = 2.21; 95% CI = 1.19-4.13) (Wetzler et al., 2007).