APC and malignant colon neoplasm: Elevation of the relative expression of APC gene was noticed in colon cancer induced group and this was in accordance with Grivennikov et al., (2012) who supported that level of APC gene expression was noticed greater in colon cancer induced group and this might be attributed to overexpression of the APC that is required as a central gatekeeper protein for regulating multiple pathways in colon cancer progression.