FLT3 and acute myeloid leukemia: However, other studies that did not reveal any age-dependency of FLT3-ITD, being performed in cohorts including other cytogenetic groups, smaller patient numbers of AML-CN, or restriction to patients up to 60 years of age (Thiede et al., 2002; Fröhling et al., 2002; Gale et al., 2005).