As previous studies showed that p16INK4A expression was associated with HR-HPV infection in oropharyngeal squamous (Liu et al., 2015), mucosal squamous cell carcinomas of the head and neck (Antonsson et al., 2015), cervical squamous intraepithelial lesion (Yildiz et al., 2007), and invasive cervical and vaginal carcinomas (Missaoui et al., 2010; Missaoui et al., 2014). The gene discussed is CDKN2A; the disease is cervical squamous intraepithelial neoplasia.