However, the groups differed significantly regarding albumin level (P value < 0.003).The present study observed a high statistically significant difference between HCC and HCV groups with regard to the type of drug regimen used; SOF+DAC+RBV was the most prevalent drug regimen in HCC group (P value < 0.001) and SOF+SIM was the safest drug regimen in the HCV group .These results are in agreement with a previous study of (Ghanem et al., 2020) who found that SOF+DAC+RBV was the most prevalent drug treatment for HCC. This evidence concerns the gene ALB and hepatocellular carcinoma.