Across the common mutations, we identified mutations of known-driver genes in NSCLC as TP53 and MAP2K1 (Wislez et al., 2021) and recurrent mutated genes in NHL as MYC, TBL1XR1, IGLL5, GNA13, and PIM1. We found a strong correlation between the variant allele frequency (VAF) on cfDNA and the somatic VAF in tumor tissue biopsy (Pearson test, ρ = 0.7–0.78, all p-value < 0.001, Supplementary Figure 4). Here, TP53 is linked to non-Hodgkin lymphoma.