Interestingly, patient FR-02-40 harbored alterations in genes associated with the activated B-cell (ABC) DLBCL subgroup (Testoni et al., 2015; Schmitz et al., 2018), such as PIK3CA, NFKBIZ, BCL2, and SPIB. The gene discussed is SPIB; the disease is diffuse large B-cell lymphoma.