For example, lncRNA BACE1-AS, which is partially antisense to BACE1 (a gene encoding the β-site amyloid precursor protein cleaving enzyme 1), has been identified to be markedly upregulated in the brains of Alzheimer’s disease patients and promotes the stability of its sense partner (BACE1) [45]. This evidence concerns the gene BACE1 and early-onset autosomal dominant Alzheimer disease.