Importantly, treatment of organoids with STmΔaroA could recapitulate effects on gene expression seen in vivo, with a substantial reduction in transcripts for Lgr5, Smoc2, and Vim in both CAC-derived and Apcmin/+-derived tumor organoids, as well as Pdk4 in Apcmin/+ organoids (expression was very low in CAC organoids) (Figure 6, C and D). Here, PDK4 is linked to neoplasm.