Later, it was examined the impact of transfection on the biological behavior of NSCLC, finding that overexpressing circSOX13 promoted A549 and H1299 proliferation, invasion and migration but inhibited apoptosis, while simultaneous transfection of si-MAPRE1 reversed them (Figure 6b-Figure 6e). This evidence concerns the gene MAPRE1 and non-small cell lung carcinoma.