The results of soft agar, ATP, CCK8 and EdU assays and flow cytometry showed that miR‐6125‐mediated downregulation of Cyclin D1 caused cell cycle G0‐G1 arrest, thereby inhibiting the proliferation of CRC cells (Figure 4G–N and Figure S2G–L). This evidence concerns the gene CCND1 and colorectal carcinoma.