During this process, inactivation of GSK3β causes β‐catenin to accumulate in the cell and translocate to the nucleus,25 where it binds to T‐cell factor/lymphoid enhancer‐binding factor 4 (TCF4) to activate the downstream target genes Cyclin D1, matrix metallopeptidase 7 (MMP7) and c‐Myc to promote the occurrence and development of tumours.39, 40, 41. This evidence concerns the gene TCF4 and neoplasm.