The above results showed that overexpression of miR‐6125 in SW480 and RKO cells with relatively low expression of miR‐6125 can inhibit YTHDF2‐GSK3β‐β‐catenin‐Cyclin D1 pathway, and further inhibited the proliferation of CRC cells. The gene discussed is YTHDF2; the disease is colorectal carcinoma.