In this study, we showed that GSK3β acts as a tumour suppressor gene; m6A‐modifed GSK3β was recognized and degraded by YTHDF2, leading to the activation of Wnt/β‐catenin signalling and further promoting the proliferation of CRC cells in vitro and in vivo. The gene discussed is ENSG00000280371; the disease is colorectal carcinoma.