We found that PI3K‐IN‐6 or MK‐2206 treatment further suppressed the proliferation, migration and invasion of RBM24‐overexpressing CRC cells; meanwhile, a synergistic effect of RBM24 overexpression in combination with either PI3K‐IN‐6 or MK‐2206 treatment on gene expression was observed in comparison with untreated controls (Figure S3). Here, RBM24 is linked to colorectal carcinoma.