Similarly, the expression of Matrix metalloproteinases 2 and 9 (MMP2 and MMP9), downstream molecules of the PI3K/Akt pathway, was markedly increased and correlated inversely with RBM24 expression, whereas P21 expression showed a significant positive correlation with RBM24 expression in tumour tissues of RBM24‐knockout mice in comparison to WT mice (Figure 4A–C). Here, AKT1 is linked to neoplasm.