A recent study has also identified that SNPs for ON risk in SLE patients include NOS3 (exon 6: c.814G > A, p.E272K), Collagen Type II Alpha 1 Chain (COL2A1, c.3508G > A, rs41263847: exon 29: c.1913C > T: p.T638I, exon 28: c.1706C > T: p.T569I, and rs371445823: exon 8: c.580G > A: p.A194T, exon 7: c.373G > A: p.A125T),125 and CR2 (rs45573035: exon 2: c.200C > G: p.T67S).125. This evidence concerns the gene NOS3 and systemic lupus erythematosus.