GOF variants in RyR2 (Table 5) are implicated in ventricular tachyarrhythmias, including type 1 of CPVT type (CPVT1), which is characterized by stress‐induced ventricular tachycardia in the absence of a structurally abnormal heart.123. The gene discussed is RYR2; the disease is catecholaminergic polymorphic ventricular tachycardia.