Indeed, CRP levels have been correlated with white matter lesions in multiple pathologies not related to COVID-19, such as cerebral small vessel disease, neurodegenerative processes and obesity (Mitaki et al. 2015; Eagen et al. 2012; Lampe et al. 2018), which may occur as comorbidities in COVID-19 encephalopathy patients. Here, CRP is linked to cerebral small vessel disease.