FBXL2 and Parkinson disease: Therefore, in view of the importance of the F-box domain in the interaction with DAT, we studied the possible association of the transporter with other F-box proteins that have been implicated in Parkinson disease (such as FBXO7 or FBXO18) [63, 64] or in the stability of FBXL2 (such as FBXO3) [65].