The mutation R615C, which results in a shift of DAT to areas devoid of GM1 ganglioside and flotillin, impacts transporter regulation and is a risk factor for the development of attention deficit/hyperactivity disorder [45, 46], an example of the importance of the interactions of DAT with the different lipid microdomains of the membrane. Here, SLC6A3 is linked to attention deficit-hyperactivity disorder.