With the increasing use of gene panel–based analyses, TP53 germline genetic testing is frequently performed in individuals who do not meet LFS genetic testing criteria,11 leading to the detection of TP53 variant carriers, which are associated with a less penetrant phenotype.11 Germline TP53 variants are also found through the increasing use of paired tumor/normal sequencing, and the American College of Medical Genetics and Genomics recommends reporting secondary and incidental TP53 findings. This evidence concerns the gene TP53 and neoplasm.