Furthermore, both BTLA and CD160 are expressed by iNKT cells, and both molecules served to attenuate production of inflammatory cytokines by iNKT cells during αGalCer-induced acute hepatitis (Kim et al., 2019; Miller et al., 2009), providing an example in which two HVEM-binding IgSF molecules are required in one cell type. This evidence concerns the gene BTLA and Acute hepatitis.