The CSCs can be identified and isolated by the expression of distinctive markers to enrich stem cells.13–15 Various CSC markers such as cluster of differentiation 44 (CD44), aldehyde dehydrogenase 1 (ALDH1), sex-determining region Y (SRY)-box 2 (SOX2), and octamer-binding protein 4 (OCT4) have been utilized to identify CSCs in HNSCC and OED.16 The gene discussed is SOX2; the disease is head and neck squamous cell carcinoma.