IRF6 and neoplasm: The transcription factor OCT4 is a regulator of the Pit-Oct-Unc domain and is critical in early embryogenesis and maintenance of embryonic stem cell pluripotency.22 Octamer-binding protein 4 (OCT4) has also been linked to oncogenic processes, and it has been suggested that OCT4 plays a role in tumor transformation, tumorigenicity, invasion, and metastasis within OSCC.23,24 It has also been proposed that OCT4 promotes tumor initiation by playing a role in the regulation of epithelial-mesenchymal transition.25