CDKN2A and leukoplakia: Saito et al. reported p16 positivity in only 12% of 57 OED cases.37 In contrast, the study by Buajeeb et al. found no p16 positivity in oral leukoplakia cases with dysplasia.38 The present study reported 25% (10/40) of p16 positivity in the OED cases examined.