HMGB1 and brain ischemia: For instance, notoginsenoside R1 protects the injury induced by hypoxia and re-oxygen deprivation via upregulation of miR-132 in H9c2 cells [43], and demedetomidine modulates miR-205-5p via targeting cerebral ischemia/reperfusion HMGB1 for repression of inflammatory response and oxidative stress [44].