Combined Z‐score of 10 EV‐mRNA (ALB, GPC3, AFP, AHSG, APOH, FABP1, FGB, FGG, RBP4, and TF) showed high diagnostic performance for HCC diagnosis from at‐risk patients (sensitivity 93.8%, specificity 74.5%, AUC 0.87) and other primary cancer (sensitivity 95.7%, specificity 89.5%, AUC 0.95).67 This evidence concerns the gene RBP4 and hepatocellular carcinoma.