Thus we next analyzed several online human cancer tissue datasets, including the Cancer Genome Atlas (TCGA) and Clinical Proteomic Tumor Analysis Consortium (CPTAC), and found that the expression of THOC2 and THOC5 was upregulated in TNBC tissues at both mRNA and protein level in comparison to normal breast tissues, and THOC5 was more specifically upregulated in human TNBC tissues (Figure S2, Supporting Information; Figure 2B). The gene discussed is THOC5; the disease is cancer.