AGER and Familial prostate cancer: Intriguingly, we found that although the RAGE rs1800625 polymorphisms were not associated with the grade group upgrade of prostate cancer (Tables 2 and 3), however, the RAGE rs1800625 genotypic variants ‘TC + CC’ were found to be significantly associated with perineural invasion of prostate cancer (p = 0.005, Table 4).