Most studies have linked the RAGE rs2070600 polymorphic variant A allele with increased cancer risk and poor prognosis of disease,16, 30, 42, 53 However, in a study of lung cancer, RAGE was suggested to act as a tumour suppressor in lung cancer development, and the variant A allele of rs2070600 was suggested to be associated with decreased expression of the tumour suppressor gene RAGE.53 This evidence concerns the gene AGER and lung cancer.