The polymorphisms of RAGE were suggested to be associated with various cancers,14, 15, 16 including oral cancer,17 breast cancer,18, 19, 20, 21, 22, 23, 24 lung cancer,25, 26, 27, 28 gastric cancer,29, 30, 31 hepatocellular carcinoma (HCC),32 pancreas cancer,33 cervical cancer,34, 35 urothelial cell carcinoma36 and colorectal cancer.37 This evidence concerns the gene AGER and lip and oral cavity carcinoma.