An UPS score ≥ 8.5 points discriminated best between CMT1A and all other neuropathies, a score ≥ 9.5 between CMT1A and other demyelinating neuropathies (ROC curve analysis AUC = 0.91 sensitivity = 0.84, specificity = 0.84 if UPSS ≥ 8.5 or AUC = 0.86 sensitivity = 0.8, specificity = 0.74 if UPSS ≥ 9.5). Here, PMP22 is linked to neuropathy.