Accumulating evidence from work mainly in cancer cell lines begins to unravel the specific recruitment of these different Atg8 proteins in phagophores facilitating the sequestration of selective cargo, such as for example the role of LC3C in piecemeal mitophagy [149] versus the role of LC3A in Parkin-independent mitophagy [150]. The gene discussed is PRKN; the disease is cancer.