On the other hand, a contrasting result was also reported in a prior study in humans (42), in which downregulation of miR-375 was observed in myocardial infarction patients and overexpression of miR-375 by mimic-miR-375 prevented hypoxia/reoxygenation-induced cardiac injury by upregulating Nemo-like kinase (NLK) gene. The gene discussed is NLK; the disease is myocardial infarction.