The rising trend of hypertension prevalence in low and middle-income countries is backed up by the direct hypothesis which proposes that malaria “directly” contributes to raised blood pressure through chronic inflammation, inflammation-driven angiopoietin-2 mediated arterial stiffness, malaria in pregnancy (leading to hypertensive disorders of pregnancy like gestational hypertension and preeclampsia and low birth weight), and childhood malnutrition in population chronically exposed to malaria (8). The gene discussed is ANGPT2; the disease is preeclampsia.