In the testing and validation cohorts, the mean densities of B cells, CD8+ T cells, CD4+ T cells, Treg cells, and M1 macrophages in the stroma were higher than the densities in tumor core (38.320, 77.234, 45.291, 26.291, and 71.248 cells/mm2 Vs 9.580, 25.745, 10.065,6.5728, and 24.568 cells/mm2, respectively). This evidence concerns the gene CD4 and neoplasm.