Some studies showed that AQP4 was poorly expressed in LUAD tissues and overexpressing AQP4 could inhibit the promotive role of miR-196b on cancer cell migration and invasion (Wu et al., 2021), while other studies found that AQP4 was upregulated in well-differentiated LUAD and higher mRNA and protein levels of AQP4 were associated with a better prognosis (Warth et al., 2011). This evidence concerns the gene AQP4 and cancer.