According to the GEPIA database, AQP1, AQP3, AQP4, and AQP9 were significantly expressed in LUAD tissues compared to normal lung tissues (p < 0.05), but some genes including AQP0, AQP5, AQP6, AQP7, AQP8, AQP10, and AQP11 were not differentially expressed between tumor and normal tissues. The gene discussed is AQP8; the disease is neoplasm.