Consistently, some clinical studies also suggested that the aberrant AQP3 expression may be strongly associated with tumor progression and prognosis in several malignant cancers, including hepatocellular carcinoma (Guo et al., 2013), colorectal carcinoma (Li et al., 2013), and gastric cancer (Chen et al., 2014). The gene discussed is AQP3; the disease is hepatocellular carcinoma.