Anthocyanins present in freeze-dried black raspberries extracts have shown to induce demethylation of secreted frizzled related protein 2 (SFRP2) promoters, and revive useful probiotics such as Eubacterium rectale, Faecalibacterium prausnitzii, and Lactobacillus in DSS/AOM colitis-CRC mice model (50). Here, SFRP2 is linked to colorectal carcinoma.