Similarly, circ-GRB10 was downregulated during IDD progression, and competitively bound to miR-328-5p to regulate NP cell apoptosis by targeting erb-b2 receptor tyrosine kinase 2 (ERBB2) in the ErbB signaling pathway (Guo et al., 2018). Here, ERBB2 is linked to intervertebral disk degenerative disorder.