CASP8 and Hypoglycemia: BID inhibition also prevented nuclear translocation of the pro-apoptotic factor AIF in models of hypoxia–hypoglycemia-induced neuronal cell death (Culmsee et al., 2005), although the role of caspase 8 in AIF release from mitochondria was not elucidated in this study, and a role for PARP activation was proposed.