However, one important caveat is that CF pigs are prone to meconium ileus that often necessitates euthanasia despite surgical efforts (Meyerholz et al., 2010b; Guillon et al., 2015), and this may preclude the use of CF pigs in studying the long-term effects of CFTR in development. The gene discussed is CFTR; the disease is cystic fibrosis.