Several recently discovered batokines, such as FGF21, NRG4, BMP8b, CXCL14, or adiponectin have been shown to exert a protective role against obesity by enhancing beiging of WAT, lipolysis, sympathetic innervation, or polarization of M2 macrophages (Ahmad et al., 2021). This evidence concerns the gene NRG4 and obesity due to melanocortin 4 receptor deficiency.