FNDC5 and Simpson-Golabi-Behmel syndrome: We reported that recombinant irisin at above 50 ng/mL induced a beige phenotype of human primary abdominal subcutaneous and Simpson-Golabi-Behmel syndrome (SGBS) adipocytes when they were treated on top the white adipogenic protocol that was used in this study (Kristóf et al., 2015; Klusóczki et al., 2019).