ERBB2 and breast carcinoma: On the same line, Grasso et al. by using SKBR3 breast cancer cells as a model of ERBB2 amplification, reported that in a transwell assay, migration was significantly decreased in p140Cap-overexpressing cells as well as increased in MDA-MB-453 p140Cap-silenced cells, an additional model of ERBB2 gene amplification.