Shen et al. (2020) found that m6A associated gene METTL3 stabilizes the expression of HK2 and SLC2A1 in colorectal cancer through the m6A-IGF2BP2/3 dependent mechanism, and enhances the glycolysis ability of tumor cells, thus promoting the progress of colorectal cancer. Wang et al. (2020) discovered that METTL3 enhanced the stability of HK2 through YTHDF1-mediated m6A modification, thus promoting the Warburg effect of cervical cancer, and finally promoting the malignant proliferation of tumors. The gene discussed is HK2; the disease is colorectal cancer.