HK2 and hepatocellular carcinoma: Chen et al. (2019) discovered that high expression of HK2 was remarkable associated with the degree of malignancy and poor prognosis of gallbladder tumors. Downregulation of HK2 expression could significantly inhibit the proliferation, migration and invasion of gallbladder cancer cells, and at the same time reduce glucose consumption and cellular lactic acid production. DeWaal et al. (2018) discovered that HK2 knockout inhibited the glycolytic effect of HCC cell, promoted the level of oxidative phosphorylation, and at the same time increased sensitivity of cancer cells to metformin.