PARP1 and schizophrenia: Additionally, adult PARP1 KO mice have a reduced brain weight, altered neuronal proliferation within the brain’s dentate gyrus (Plane et al., 2012) and subventricular zone (Hong et al., 2019), and display schizophrenia-like behaviors, including defects in pre-pulse inhibition, decreased social interaction, and increased anxiety-like behaviors (Hong et al., 2019).