Encouragingly, subgroup analysis forest maps suggested that the hematological risk score generated by the HRM was an independent risk factor for the progression of AM in different subgroups, regardless of age, tumor size, tumor location, presence of PTBE, EOR, Ki-67 index level, or PORT (HR > 1, P < 0.05; Figure 5A), which further reflected the excellent stability and universality of the HRM. Here, MKI67 is linked to acute myeloblastic leukemia with maturation.