PIAS3 and neoplasm: BC tumor exosomal miR-9 and miR-181a activated the JAK/STAT signaling pathway by targeting SOCS3 and PIAS3 respectively, and thus consequentially promoting the development and immunosuppressive function of mice early-stage myeloid-derived suppressor cells (eMDSCs), resulted in T-cell immunity inhibition and tumor progress (62).