Moreover, although fuco-SERPINA1, or SERPINA1, is less able to recognize PC patients than CA 19-9 (AUC: 0.652/0.836 vs. 0.914), fuc-Serpina1 may improve CA 19-9’s ability to recognize PC (AUC = 0.956). The gene discussed is SERPINA1; the disease is pachyonychia congenita.