Moreover, it has been verified that elevated expression of CDK5R1, GNPNAT1, LDHA is tightly associated with worse prognosis in diverse cancers including hepatocellular carcinoma, oral squamous cell carcinoma et al. (Zeng et al., 2021; Zheng et al., 2020; Cai et al., 2019). This evidence concerns the gene CDK5R1 and oral cavity squamous cell carcinoma.