Moreover, it has been verified that elevated expression of CDK5R1, GNPNAT1, LDHA is tightly associated with worse prognosis in diverse cancers including hepatocellular carcinoma, oral squamous cell carcinoma et al. (Zeng et al., 2021; Zheng et al., 2020; Cai et al., 2019). The gene discussed is CDK5R1; the disease is cancer.