TP53 and neoplasm: Nonetheless, the p53 protein was reported to be aninformative, predictive genetic marker of acute toxicity or response to theradiation therapy of native tumors [138].By analyzing the expression of p53 and a number ofother genes, researchers have predicted the absorbed dose at which a particulartumor response is elicited[139, 140].Gendicine (Ad-p53), arecombinant adenovirus engineered to express wild-type p53 in the tumor wherethis protein is mutated, can be considered a successful application ofp53-targeting therapy.