The thiazole derivative of quinoneRO-3306, an inhibitor of CCNB1/Cdk1, induces p53-mediated apoptosis ofp53-intact neuroblastoma cells [114].Luteolin, which causes Mdm2 degradation, can inhibit cyclin D1 and CDK2/4, thusincreasing the level of p53 expression in the cell [115]. The gene discussed is TP53; the disease is neuroblastoma.