Importantly, Snail activity depends on the p53 status.Thus, the mutant forms of p53 cause overexpression of Snail and Slug, which isrelated to the acquisition of radioresistance by ovarian cancer cells: theseproteins increase the survivability of precursor cells thanks to the activationof the SCF/c-Kit signaling pathway [47]. This evidence concerns the gene TP53 and ovarian cancer.