IGFBP3 and neoplasm: The miR-21 targets include the genespromoting apoptosis (PDCD4 and LRRFIP1)[99, 100], as well as the tumor suppressor genes inhibitinginvasion (RECK and TIMP3) [101] and proliferation(IGFBP3) [87].Furthermore, miR-21 can affect microglial behavior, thus ensuring favorableconditions for tumor growth.