GAS5interacts with the DNA-binding domain of the receptors of steroid hormones(glucocorticoids, mineralcorticoids, androgens, and progesterone), thuspreventing them from impacting the target genes [64]. In vitro experiments have demonstratedthat lncRNA GAS5 acts as a tumor suppressor in gliomas. The gene discussed is GAS5; the disease is central nervous system cancer.