The presence of p53 as a significant tumour suppressor plays a crucial role in the prevention of cell death and cell proliferation while mutation could happen in more than 50% of human cancers; however, in a normal cell, it has been stated that the damage of DNA in p53 could stimulate the G1 cell cycle arrested by p21 to enhance the process involved in the repair mechanisms or cell death which naturally prevent the production of genetically transmuted cell clones. Here, TP53 is linked to cancer.